Publications arising from the Cambridge City over – 75s Cohort Study

Journal publications

• CC75C study design and overview
• Dementia and dementia sub-types
• Neuropsychology
• Neurobiology
• Genetics
• Logitudinal perspectives
• Clinical practice and services for the oldest old

CC75C study design and overview

Cohort profile: the Cambridge City over-75s Cohort (CC75C)
Fleming J, Zhao E, O’Connor DW, Pollitt PA, Brayne C.
Int J Epidemiol. 2007 Feb;36(1):40-6.

An epidemiological study of the dementias in Cambridge: from clinical progression to neuropathology.
Brayne C, Huppert FA, Xuereb JH, Gertz H-J, Chi L-Y, McGee MA, Paykel ES, Harrington C, Mukaetova-Ladinska E, O’Sullivan A, Dening T, Freer C and Wischik CM.
In: Iqbal K, Winblad B, Nichimura T, Takeda M and Wisniewski HM (Eds) Alzheimer’s disease: biology, diagnosis and therapeutics. John Wiley & Sons Ltd., 1997, pp 11-20.

The Cambridge Project for Later Life: Design and preliminary results.
Brayne C, Huppert F, Paykel E and Gill C.
Neuroepidemiology, 1992; 11(Suppl 1): 71-75.

Dementia and dementia sub-types

Lack of associations between modifiable risk factors and dementia in the very old: Findings from the Cambridge City over-75s Cohort Study
Kay Deckers, Sebastian Köhler, Martin van Boxtel, Frans Verhey, the CC75C study collaboration, Carol Brayne, Jane Fleming
Aging and Mental Health e-pub: 2 February 2017, doi.org/10.1080/13607863.2017.1280767

Health-related quality of life in the Cambridge City over-75s Cohort (CC75C): development of a dementia-specific scale and descriptive analyses.
Perales J, Cosco TD, Stephan BC, Fleming J, Martin S, Haro JM, Brayne C; CC75C Study.
BMC Geriatr. 2014 Feb 10;14:18. doi: 10.1186/1471-2318-14-18.

What do we mean by Alzheimer’s disease?
Marcus Richards, Carol Brayne
BMJ, 2010, 341:c4670

Vascular risk factors and incident dementia: results from a cohort study of the very old.
Brayne C, Gill C, Huppert FA, Barkley C, Gehlhaar E, Girling DM, O’Connor DW and Paykel ES.
Dementia, 1998; 9: 175-180.

Incidence of dementia and cognitive decline in over-75s in Cambridge: Overview of cohort study.
Paykel ES, Huppert FA and Brayne C.
Social Psychiatry and Psychiatric Epidemiology, 1998; 33: 387-392.

The incidence of clinically diagnosed subtypes of dementia in an elderly population. Cambridge Project for Later Life.
Brayne C, Gill C, Huppert FA, Barkley C, Gehlhaar E, Girling D, O’Connor D and Paykel E.
British Journal of Psychiatry, 1995; 167: 255-262.

Cognitive decline in an elderly population; a two-wave study of change.
Brayne C, Gill C, Paykel ES, Huppert FA and O’Connor DW.
Psychological Medicine, 1995; 25: 673-683.

Incidence of dementia in a population older than 75 years in the United Kingdom.
Paykel ES, Brayne C, Huppert FA, Gill C, Barkley C, Gehlhaar E, Beardsall L, Girling DM, Pollitt P and O’Connor D.
Archives of General Psychiatry 1994; 51: 325-332.

The EURODEM collaborative re-analysis of case-control studies of Alzheimer’s disease: implications for public health.
Brayne C.
International Journal of Epidemiology, 1991; 20(Suppl 2): 568-571.

Continued clinical validation of dementia diagnosed in the community using the Cambridge Mental Disorders of the Elderly Examination.
O’Connor DW, Pollitt PA, Jones BJ, Hyde JB, Fellowes JL and Miller ND
Acta Psychiatrica Scandinavica, 1991; 83: 41-45.

The influence of education and social class on the diagnosis of dementia in a community population.
O’Connor DW, Pollitt PA and Treasure FP.
Psychological Medicine, 1991; 21: 219-224.

The Prevalence of Dementia in Europe: a collaborative study of 1980-l990 findings.
Rocca WA, Brayne C, Breteler MMB, Clarke M, Cooper B, Copeland JRM, Dartigues JF, Hofman A, Hagnell O, Heeren TJ, Engedal K, Jonker C, Lindesay J, Lobo A, Mann AH, Molsa PK, Morgan K, O’Connor DW, Sulkava R, Kay DW, Amaducci L, and Da Silva Droux A.
International Journal of Epidemiology, 1991, 20: 736-748.

Frequency and Distribution of Alzheimer’s Disease in Europe: a collaborative study of l980-l990 prevalence findings.
Engedal K, Hagnell O, Heeren TJ, Jonker C, Lindesay J, Lobo A, Mann AH, Molsa PK, Morgan K, Da Silva Droux A, Sulkava R, Kay DW, Amaducci L and Dartigues JF.
Annals of Neurology, 1991; 30: 381-390.

The Prevalence of Vascular Dementia in Europe: Facts and Fragments from 1980-1990 Studies.
Hagnell O, Heeren TJ, Jonker C, Lindesay J, Lobo A, Mann AH, Molsa PK, Morgan K, O’Connor D, da Silva A, Sulkava R, Kay DWK, Amaducci L, Engedal K.
Annals of Neurology, 1991, 30: 817-824.

Memory complaints and impairment in normal, depressed and demented elderly persons identified in a community survey.
O’Connor DW, Pollitt PA, Brook CPB and Reiss BB.
Archives General Psychiatry, 1990; 47: 224-227.

Problems reported by relatives in a community study of dementia.
O’Connor DW, Pollitt PA and Reiss BB.
British Journal of Psychiatry, 1990; 156: 835-841.

Co-existing depression and dementia in a community survey of the elderly.
O’Connor DW, Pollitt PA and Roth M.
International Psychogeriatrics, 1990; 2(1)

The contribution of CAMDEX to the Diagnosis of Mild Dementia in Community Surveys.
O’Connor DW.
Psychiatric Journal of University of Ottawa, 1990, 15(4): 216-20.

A follow-up study of dementia diagnosed in the community using the Cambridge Mental Disorders of the Elderly Examination.
O’Connor DW, Pollitt PA, Hyde JB, Fellowes JL, Miller ND and Roth M.
Acta Psychiatrica Scandinavica, 1990; 81: 78-82.

The prevalence of dementia as measured by the Cambridge Mental Disorders of the Elderly Examination.
O’Connor DW, Pollitt PA, Hyde JB, Fellows JL, Miller ND, Brook CPB, Reiss BB and Roth M.
Acta Psychiatrica Scandinavica, 1989; 79: 190-198.

The validity of informant histories in a community study of dementia.
O’Connor DW, Pollitt PA, Brook CP and Reiss BB.
International Journal of Geriatric Psychiatry, 1989; 4: 203-208.

Mild dementia: Perceptions and problems.
Pollitt PA, O’Connor DW and Anderson I.
Ageing and Society, 1989; 9: 261-275.

The influence of education, social class and sex on Mini-Mental State scores.
O’Connor DW, Pollitt PA, Treasure FP, Brook CP and Reiss BB.
Psychological Medicine, 1989; 19: 771-776.

Neuropsychology

A comparison of parametric models for the investigation of the shape of cognitive change in the older population.
Graciela Muniz, Fiona Matthews, Carol Brayne
BMC Neurology 2008, 8:16

Decline across different domains of cognitive funtion in normal aging: results of a longitudinal population-based study using CAMCOG.
Cullum S, Huppert FA, McGee M, Dening T, Ahmed A, Paykel ES and Brayne C.
International Journal of Geriatric Psychiatry, 2000; 15(9): 853-62.

Cognitive functions in UK community-dwelling African Caribbean and white elders: a pilot study.
Richards M, Brayne C, Dening TR, Abas M, Carter J, Price M, Jones C and Levy R.
International Journal of Geriatric Psychiatry, 2000; 15: 621-630

Population norms for the MMSE in the very old: estimates based on longitudinal data.
Dufouil C, Clayton D, Brayne C, Chi LY, Dening TR, Paykel ES, O’Connor DW, Ahmed A, McGee MA and Huppert FA.
Neurology, 2000; 55: 1609-1613

Short NART, CCRT and Spot-the-Word: Comparisons in older and demented persons.
Beardsall L and Huppert FA.
British Journal of Clinical Psychology 1997; 36(4): 619-622.

Psychometric properties of the CAMCOG and its efficacy in the diagnosis of dementia.
Huppert FA, Jorm AF, Brayne C, Girling DM, Barkley C, Beardsall L and Paykel ES.
Aging, Neuropsychology and Cognition, 1996; 3(3): 201-214.

CAMCOG – A concise neuropsychological test to assist dementia diagnosis: Socio-demographic determinants in an elderly population sample.
Huppert FA, Brayne C, Gill C, Paykel ES and Beardsall L.
British Journal of Clinical Psychology 1995; 34: 529-541.

Improvement in NART word reading in demented and normal older persons using the Cambridge Contextual Reading Test.
Beardsall L and Huppert FA.
Journal of Clinical and Experimental Neuropsychology 1994; 16(2): 232-242.

Prospective memory impairment as an early indicator of dementia.
Huppert FA and Beardsall L.
Journal of Clinical and Experimental Neuropsychology 1993; 15(5): 805-821.

A comparison of clinical, psychometric and behavioural memory tests: findings from a community study of the early detection of dementia.
Beardsall L and Huppert FA.
International Journal of Geriatric Psychiatry 1991; 6: 295- 306.

The influence of education, social class and sex on Mini-Mental State scores.
O’Connor DW, Pollitt PA, Treasure FP, Brook CP and Reiss BB.
Psychological Medicine, 1989; 19: 771-776.

The reliability and validity of the Mini-Mental State in a British community survey.
O’Connor DW, Pollitt PA, Hyde JB, Fellows JL, Miller ND, Brook CP and Reiss BB.
Journal of Psychiatric Research, 1989; 23(1): 87-96.

Neurobiology

Hippocampal sclerosis, hippocampal neuron loss patterns and TDP-43 in the aged population.  
Suvi R. K. Hokkanen† , Sally Hunter†, Tuomo M. Polvikoski, Hannah A. D. Keage, Thais Minett, Fiona E. Matthews , Carol Brayne, CFAS and CC75C study group.
Brain Pathology Accepted on-line 18 August 2017

Delirium accelerates cognitive decline in late life: a neuropathological study in 987 individuals from three population-based cohort studies
Daniel H.J. Davis, Graciela Muniz Terrera, Hannah A.D. Keage, Blossom C.M. Stephan, Jane Fleming, Paul G. Ince, Fiona E. Matthews, Colm Cunningham, E. Wesley Ely, Alasdair M.J. MacLullich, Carol Brayne, on behalf of the EClipSE Collaborative Members
JAMA Psychiatry. doi:10.1001/jamapsychiatry.2016.3423

Re-examining tau-immunoreactive pathology in the population: Granulovacuolar degeneration and neurofibrillary tangles
Hunter, S., Minett, T., Polvikoski, T., Mukaetova-Ladinska, E., & Brayne, C.
Alzheimers Res Ther, 2015 Aug, 7(1), 57. doi: 10.1186/s13195-015-0141-2

TDP-43 Pathology in the Population: Prevalence and Associations with Dementia and Age.
Keage HA, Hunter S, Matthews FE, Ince PG, Hodges J, Hokkanen SR, Highley JR, Dening T, Brayne C.
J Alzheimers Dis. 2014 Jan 1;42(2):641-50. doi: 10.3233/JAD-132351.

The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD
Hunter S, Arendt T, Brayne C.
Mol Neurobiol. 2013 Apr 3

Neuropathological correlates of falling in the CC75C population-based sample of the older old
Richardson K, Hunter S, Dening T, Xuereb JH, Matthews FE, Brayne C, Fleming J and the Cambridge City over-75s Cohort (CC75C) study neuropathology collaboration
Curr Alzheimer Res. 2012 Jul;9(6):697-708.

Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems.
Hunter S, Brayne C.
Alzheimers Res Ther. 2012 Apr 13;4(2):10.

Impact of Less Common and “Disregarded” Neurodegenerative Pathologies on Dementia Burden in a Population-Based Cohort
Hannah A.D. Keagea, Paul G. Ince, Fiona E. Matthews, Stephen B. Wharton, Ian G. McKeith, Carol Brayne on behalf of MRC CFAS and CC75C Cognitive Neuroscience Laboratory, School of Psychology
Journal of Alzheimer’s Disease 28 (2012) 485–493. DOI 10.3233/JAD-2011-111268

Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype
Stephen James Connelly, Elizabeta B Mukaetova-Ladinska, Zeinab Abdel All, Joaquim Alves da Silva, Carol Brayne, William G Honer and David M A Mann
Neuropathology and Applied Neurobiology 2011 Jun;37(4):366-80.

Education, the brain and dementia: neuroprotection or compensation?
EClipSE Collaborative Members. (2010). Brain, 133; 2210–2216.
(There was much press interest, with nearly 200 articles written world wide including ABC (USA), Sydney Morning Herald (Australia), The Toronto Star (Canada), Scientific American, The Independent (UK) and BBC (UK).)

Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge City over-75s Cohort (CC75C) study
Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH, Paykel E, Mukaetova-Ladinska EB, Huppert FA, O’Sullivan A, Dening T, and the Cambridge City over-75s Cohort (CC75C) study neuropathology collaboration
Journal of Alzheimer’s Disease, 2009 Aug;18(3) 645-658

Lewy Body Variant of Alzheimer’s Disease: Selective Neocortical Loss of t-SNARE Proteins and Loss of MAP2 and Alpha-Synuclein in Medial Temporal Lobe
Mukaetova-Ladinska, Elizabeta B; Xuereb, John H; Garcia-Sierra, Francisco ; Hurt, Jenny ; Gertz, Herman-J ; Hills, Richard ; Brayne, Carol ; Huppert, Felicia A; Paykel, Eugene S; McGee, Magnus A; Jakes, Ross ; Honer, William G; Harrington, Charles R; Wischik, Claude M
TheScientific World JOURNAL, 2009, 9, 1463-1475

Time for a Change in the Research Paradigm for Alzheimer’s Disease: The Value of a Chaotic Matrix Modeling Approach
Sally Hunter,Robert P. Friedland,Carol Brayne.
CNS Neuroscience & Therapeutics 2009 12 16 (4); 254-262.

Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals
Downes EC, Robson J, Grailly E, Abdel-All Z, Xuereb J, Brayne C, Holland A, Honer WG and Mukaetova-Ladinska EB
Neuropathology and Applied Neurobiology 2008 , 34, 12–22

Alpha and gamma-Synuclein proteins are present in cerebrospinal fluid and are increased in elderly with neurodegenerative and vascular changes
Mukaetova-Ladinska EB, Milne J, Andras A, Greally E, Robson J, Abdel-All Z, Cerejeira J, Jaros E, Perry R, Brayne C, Xuereb J, Cleghorn A, Doherty J, McIntosh G, Milton I and McKeith IG
Dementia and Geriatric Cognitive Disorders 2008;26(1):32-42. Epub 2008 Jun 25

Population-based neuropathological studies of dementia: design, methods and areas of investigation – a systematic review
Zaccai J, Ince P and Brayne C
BMC Neurology 2006, 6:2

a-Synuclein inclusions in Alzheimer’s and Lewy body diseases.
Mukaetova-Ladinska E.B, Hurt J., Jakes R., Xuereb J., Honer W.G. and Wischik C.M.
J Neuropathol Exp Neurology, 2000; 59: 408-417

Neuropathological findings in the very old: Results from the first 101 brains of a population based longitudinal study of dementing disorders.
Xuereb J, Brayne C, Dufouil C, Gertz H, Wischik C, Harrington C, Mukaetova-Ladinska E, McGee MA, O’Sullivan A, O’Connor D, Paykel ES and Huppert FA.
Ann NY Acad Sci (Suppl), 2000; 903: 490-496.

Staging of cytoskeletal and b-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer’s Disease.
Mukaetova-Ladinska EB, Garcia-Siera F, Hurt J, Gertz H-J, Xuereb JH, Hills R, Brayne C, Huppert FA, Paykel ES, McGee M, Jakes R, Honer W, Harrington CR and Wischik CM.
Am J Pathol, 2000; 157: 623-636.

Examination of the validity of the hierarchical model of neuropathological staging in normal ageing and Alzheimer’s Disease.
Gertz H-J, Xuereb J, Huppert FA, Brayne C, McGee MA, Paykel ES, Harrington C, Mukaetova-Ladinska E, Arendt T and Wischik CM.
Acta Neuropathologica, 1998; 95: 154-158.

The relationship between clinical dementia and neuropathological staging (Braak) in a very elderly community sample.
Gertz H-J, Xuereb J, Huppert F, Brayne C, Kruger H, McGee MA, Paykel ES, Harrington C, Mukaetova- Ladinska E, O’Connor DW and Wischik CM.
European Archives of Psychiatry and Clinical Neuroscience, 1996; 246(3): 132-136.

Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer’s disease.
Wischik CM, Lai RYK, Gertz HJ, Edwards CR, Xuereb JH, Paykel ES, Brayne C, Huppert FA, Mukaetova-Ladinska EB, Roth M and Harrington CR.
Neurobiology of Aging 1995; 16(3): 409-431.

Examination of phosphorylated tau protein as a PHF-Precursor at early stage Alzheimer’s disease.
Lai RYK, Gertz HJ, Wischik CM, Xuereb JH, Mukaetova-Ladinska EB, Harrington CR, Edwards PC, Mena R, Paykel ES, Brayne C, Huppert FA and Roth M.
Neurobiology of Aging 1995; 16(3): 433-445.

The response of elderly community residents to request brain donation: An interim report
Lynn Beardsall 1, Claire Barkley 1, Angela O’Sullivan 2
Int J of Geriatric Psychiatry, 1992; 7(3): 199-202.

Genetics

Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts
Suvi R. K. Hokkanen, Mia Kero, Karri Kaivola, Sally Hunter, Hannah A. D. Keage, Anna Kiviharju, Anna Raunio, Pentti J. Tienari, Anders Paetau, Fiona E. Matthews, Jane Fleming, Caroline Graff, Tuomo M. Polvikoski, Liisa Myllykangas and Carol Brayne on behalf of the EClipSE collaboration Brain Pathol e-pub 3 Aug 2019, DOI:10.1111/bpa.12773

Candidate Gene Association Studies of Genes Involved in Neuronal Cholinergic Transmission in Alzheimer’s Disease suggests Choline Acetyltransferase as a candidate deserving further study.
Cook LJ, Ho LW, Wang L, Terrenoire E, Brayne C, Grimley Evans J, Xuereb J, Cairns NJ, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Williams J and Rubinsztein DC.
Am J Med Genet (Neuropsychiatric Genetics) 2005 Jan 5;132(1):5-8.

Candidate Gene Association Studies of the a4 (CHRNA4) and ž2 (CHRNB2) Neuronal Nicotinic Acetylcholine Receptor Subunit Genes in Alzheimer’s Disease.
Cook LJ, Ho Lw, Taylor AE, Brayne C, Grimley Evans J, Xuereb J, Cairns NJ, Pritchard A, Lemmon H, Mann D, St Clair D, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Owen MJ, Williams J, Lendon C and Rubinsztein DC.
Neuroscience Letters 2004; 358: 142-146.

No evidence for an association between Saitohin Q7R polymorphism and Alzheimer’s disease.
Cook L, Brayne CE, Easton D, Grimley Evans J, Xuereb J, Cairns NJ and Rubinsztein DC.
Annals of Neurology 2002; 52(5): 690-691.

Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes.
Taylor A, Ezquerra M, Bagri G, Yip A, Goumidi L, Cottel D, Easton D, Grimley Evans J, Xuereb J, Cairns NJ, Amouyel P, Chartier-Harlin M-C, Brayne C and Rubinsztein DC.
American Journal of Medical Genetics 2001; 105: 761-4.

ApoE and apo CI loci are associated with dementia in younger but not in older late onset cases.
Tysoe C, Galinsky D, Robinson D, Brayne CE, Huppert FA, Dening T, Paykel ES, Easton DF and Rubinsztein DC.
Dementia and Geriatric Cognitive Disorders, 1998; 9: 191-198.

Analysis of the Apo E/Apo CI, angiotensin converting enzyme and methylenetetrahydrofolate reductase loci as candidates affecting human longevity.
Galinsky D, Tysoe C, Brayne C, Easton D, Huppert F, Dening T, Paykel ES and Rubinsztein DC.
Atherosclerosis, 1997; 129: 177-183.

Analysis of Alpha-1 Antichymotrypsin, Presenilin-1, Angiotensin Converting-Enzyme and Methylenetetrahydrofolate Reductase Loci as candidates for dementia.
Tysoe C, Galinsky D, Robinson D, Brayne CE, Easton DF, Huppert FA, Dening T, Paykel ES and Rubinsztein DC.
American Journal of Medical Genetics (Neuropsychiatric Genetics), 1997; 74, 207-212.

The tRNA Gln 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before age 75 years
Tysoe C, Robinson D, Brayne C, Dening T, Paykel ES, Huppert FA and Rubinsztein DC.
Journal of Medical Genetics, 1996; 33: 1002-1006.

Apolipoprotein E genotype and the prediction of cognitive decline and dementia: a prospective study of the very elderly.
Brayne C, Harrington C, Wischik C, Huppert FA, Chi LY, Xuereb J, O’Connor D and Paykel ES.
Dementia, 1996; 7: 169-174.

Longitudinal perspective

A novel examination of successful aging trajectories at the end of life.
Cosco, T.D., Muniz, G., Stephan, B.C., Brayne, C.
Can J Aging. 2016 Dec;35(4):533-540. Epub 2016 Oct 25.

(Unsuccessful) binary modeling of successful aging in the oldest-old adults: a call for continuum-based measures.
Cosco TD, Stephan BC, Brayne C.
J Am Geriatr Soc 2014 Aug;62(8):1597-8.

A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.
Chatfield M, Brayne C and Matthews F
Journal of Clinical Epidemiology 2005, 58(1) 13-19

Longitudinal studies of ageing: a key role in the evidence base for improving health and quality of life in older adults.
Huppert Felicia A., Brayne Carol, Jagger Carol and Metz David.
Age and Ageing, 2000; 29: 485-486.

Population norms for the MMSE in the very old – Estimates based on longitudinal data.
Dufouil C, Clayton D, Brayne C, Chi L-Y, Dening TR, Paykel ES, O’Connor DW, Ahmed A, McGee MA and Huppert FA.
Neurology, 2000; 55: 1609-1613.

Estimating the true extent of cognitive decline in the old old.
Brayne C, Spiegelhalter DJ, Dufouil C, Chi L-Y, Dening TR, Paykel ES, O’Connor DW and Ahmed A, McGee MA, Huppert FA.
Journal of the American Geriatrics Society, 1999; 47(11): 1283-8.

Changes in health, disability and contact with services in a very elderly cohort: A six year follow-up study.
Dening TR, Chi L-Y, Brayne C, Huppert FA, Paykel ES and O’Connor DW.
Age and Ageing, 1998; 27: 23-33.

Cognitive Impairment in elderly people: population based estimate of the future in England, Scotland and Wales.
Melzer D, Ely M and Brayne C.
British Medical Journal, 1997; 315(23): 462.

Clinical practice and services for the oldest old

When frail older people relocate in very old age who makes the decision?
Fiona Scheibl, Morag Farquhar, Jackie Buck, Stephen Barclay, Carol Brayne and Jane Fleming on behalf of the Cambridge City over-75s Cohort (CC75C) study collaboration
Innovation in Aging Volume 3, Issue 4, August 2019, igz030, DOI: 10.1093/geroni/igz030

Longitudinal analysis of the impact of loneliness on cognitive function over a 20-year follow-up
Hanyuying Wang, Caroline Lee, Sally Hunter, Jane Fleming, Carol Brayne and The CC75C study collaboration
Aging and Mental Health e-pub 20 Aug 2019, DOI: 10.1080/13607863.2019.1655704

The experience of transitions in care in very old age: implications for general practice
Fiona Scheibl, Jane Fleming, Jackie Buck, Stephen Barclay, Carol Brayne and Morag Farquhar on behalf of the Cambridge City over-75s Cohort (CC75C) study collaboration
Family Practice e-pub June 2019, DOI: 10.1093/fampra/cmz014

Is loneliness associated with increased health and social care utilisation in the oldest old? Findings from a population-based longitudinal study
Hanyuying Wang, Emily Zhao, Jane Fleming, Tom Dening, Kay-Tee Khaw, Carol Brayne & The CC75C Study Collaboration
BMJ Open 2019;9:e024645

Mortality risk of loneliness in the oldest old over a 10-year follow-up
Hanyuying Wang, Yue Leng, Emily Zhao, Jane Fleming, Carol Brayne & The CC75C Study Collaboration
Aging & Mental Health, e-pub 17 Nov 2018. DOI: 10.1080/13607863.2018.1510897

Dying comfortably in very old age with or without dementia in different care settings – a representative “older old” population study.
Jane Fleming, Rowan Calloway, Anouk Perrels, Morag Farquhar, Stephen Barclay, Carol Brayne on behalf of the CC75C Cambridge City over-75s Cohort study collaboration
BMC Geriatrics 2017 17/222 DOI 10.1186/s12877-017-0605-2

Death and the oldest old: Attitudes and preferences for end-of-life care – Qualitative research within a population-based cohort study
Jane Fleming, Morag Farquhar, CC75C study collaboration, Carol Brayne, Stephen Barclay
PLOS ONE 2016 April 5,DOI:10.1371/journal.pone.0150686
Featured on BuzzFeed: http://www.buzzfeed.com/tomchivers/the-only-thing-im-worried-about-is-my-sister
Featured on The Conversation: http://theconversation.com/heres-what-people-in-their-90s-really-think-about-death-58053

The relationship between back pain and mortality in older adults varies with disability and gender – results from the Cambridge over-75s Cohort (CC75C) study
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones and the Cambridge City over-75s Cohort (CC75C) study collaboration
European Journal of Pain Published online: 28 JUL 2014 DOI: 10.1002/ejp.568

Pain reporting in older adults: the influence of cognitive impairment – results from the Cambridge City >75 Cohort study
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones and the Cambridge City over-75s Cohort (CC75C) study collaboration
British Journal of Pain (e-pub 10 Apr 2014 http://dx.doi.org/10.1177/2049463714527437)

Health-related Quality of Life in the Cambridge City over-75s Cohort (CC75C). Development of dementia-specific scale and descriptive analyses.
J Perales, TD Cosco, BCM Stephan, J Fleming, S Martin, JM Haro, C Brayne
BMC Geriatrics 2014 14:18 doi:10.1186/1471-2318-14-18

Place of death and end-of-life transitions experienced by very old people with differing cognitive status: retrospective analysis of a prospective population-based cohort aged 85 and over
Anouk J. Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M. Buiting, Carol Brayne and the Cambridge City over-75s Cohort (CC75C) study collaboration
Palliative Medicine, 2014 Mar 3;28(3):220-233 (e-pub ahead of print Dec 2013)

Education associated with a delayed onset of terminal decline.
Terrera GM, Minett T, Brayne C, Matthews FE.
Age Ageing. 2013 Oct 17.

Epidemiology of back pain in older adults: prevalence and risk factors for back pain onset
Rachael E. Docking, Jane Fleming,Carol Brayne,Jun Zhao,Gary J. Macfarlane and Gareth T. Jones on behalf of the Cambridge City over-75s Cohort Study collaboration
Rheumatology (2011) doi: 10.1093/rheumatology/ker175 First published online: May 23, 2011

Are terminal decline and its potential indicators detectable in population studies of the oldest old?
Muniz-Terrera G, Matthews FE, Stephan B, Brayne C; CC75C Collaboration Group.
Int J Geriatr Psychiatry. 2011 Jun;26(6):584-92. doi: 10.1002/gps.2566. Epub 2010 Dec 9.

The “oldest old” in the last year of life: population-based findings from CC75C study participants aged at least 85 at death
Zhao J, Barclay S, Farquhar M, Kinmonth AL, Brayne C and Fleming J for the Cambridge City over-75s Cohort (CC75C) study collaboration
Journal of the American Geriatrics Society. 2010 Jan;58(1):1-11.

Place of death for the ‘oldest old’: > or =85-year-olds in the CC75C population-based cohort.
Fleming J, Zhao J, Farquhar M, Brayne C, Barclay S for the Cambridge City over-75s Cohort (CC75C) study collaboration
Br J Gen Pract. 2010 Apr;60(573):171-9.

One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors.
Terrera GM, Brayne C, Matthews F; CC75C Study Collaboration Group.
Int Psychogeriatr. 2010 Mar;22(2):291-9. Epub 2009 Nov 12.

Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study.
Jane Fleming, Fiona E Matthews, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
BMC Geriatrics 2008, 8:6 doi:10.1186/1471-2318-8-6

Inability to get up after falling, subsequent time on floor, and summoning help: prospective cohort study in people over 90.
Jane Fleming, Carol Brayne, and the Cambridge City over-75s Cohort (CC75C) study collaboration.
BMJ 2008;337:a2227.

Very old drivers: findings from a population cohort of people aged 84 and over.
Brayne C, Ahmed A, Dening TR, Chi L-Y, McGee M and Huppert FA.
International Journal of Epidemiology, 2000; 29: 704-707

Disability and contact with services in very elderly people.
Dening TR and Gabe R.
Reviews in Clinical Gerontology, 2000; 10: 291-309

Estimating the numbers and characteristics of elderly people with cognitive disability in local populations.
Ely M, Melzer D, Opit L and Brayne C.
Research Policy and Planning, 1996/1997; 14: 13-18.

Local Population Differences and the Needs of People with Cognitive Impairment.
Melzer D, Ely M and Brayne C.
International Journal of Geriatric Psychiatry, 1997; 12:883-887.

Cognitive impairment: a challenge for community care. A comparison of the domiciliary service receipt of cognitively impaired and equally dependent physically impaired elderly women.
Ely M, Brayne C, Huppert FA, O’Connor DW and Pollitt PA.
Age and Ageing, 1997; 26: 301-308.

Suicidal thinking in community residents over eighty.
Rao R, Dening T, Brayne C and Huppert FA.
International Journal of Geriatric Psychiatry, 1997; 12: 337-343.

Attitudes towards death – a community study of octo- and nonagenerians.
Rao R, Dening T, Brayne C and Huppert F.
International Psychogeriatrics, 1997; 9(2): 213-221.

Depressive symptoms in the very elderly – their prevalence and significance.
Girling DM, Huppert FA, Brayne C, Paykel ES, Gill C and Mathewson D.
International Journal of Geriatric Psychiatry, 1995; 10: 497-504.

The prevalence of depression in a cohort of the very elderly.
Girling DM, Barkley C, Paykel ES, Gehlhaar E, Brayne C, Gill C, Mathewson D and Huppert FA.
Journal of Affective Disorders, 1995; 34: 319-329.

Predictors of hospital contact by very elderly people: a pilot study from a cohort of people aged 75 years and over.
Chi L-Y, Brayne C, Todd CJ, O’Connor DW, Pollitt PA.
Age and Ageing, 1995 Sep; 24(5): 382-8

Something in the heir: royal succession and the elderly.
Dening TR Brayne C Huppert FA and Rao MR.
International Journal of Geriatric Psychiatry, 1994; 9: 675.

Does early intervention reduce the number of elderly people with dementia admitted to institutions for long term care?
O’Connor DW, Pollitt PA, Brook CPB, Reiss BB and Roth M.
British Medical Journal, 1991; 302: 871-875.

A community survey of mental and physical infirmity in nonagenarians.
O’Connor DW, Pollitt PA, Brook CPB and Reiss BB.
Age and Ageing, 1989; 18: 411-414.

The distribution of services to demented elderly people living in the community.
O’Connor DW, Pollitt PA, Brook CPB and Reiss BB.
International Journal of Geriatric Psychiatry, 1989; 4: 339-344.

Practice observed: Do general practitioners miss dementia in elderly patients?
O’Connor D, Pollitt PA, Brook CP, Reiss BB and Roth M.
British Medical Journal, 1988; 297: 1107-1110.