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Publications arising from
the Cambridge City over - 75s Cohort Study
Journal publications
CC75C study design and overview
The Cambridge Project for Later Life: Design and preliminary results.
Brayne C, Huppert F, Paykel E and Gill C.
Neuroepidemiology, 1992; 11(Suppl 1): 71-75.
An epidemiological study of the dementias in Cambridge: from clinical progression to neuropathology.
Brayne C, Huppert FA, Xuereb JH, Gertz H-J, Chi L-Y, McGee MA, Paykel ES, Harrington C, Mukaetova-Ladinska E, O'Sullivan A, Dening T, Freer C and Wischik CM.
In: Iqbal K, Winblad B, Nichimura T, Takeda M and Wisniewski HM (Eds) Alzheimer's disease: biology, diagnosis and therapeutics. John Wiley & Sons Ltd., 1997, pp 11-20.
Cohort profile: the Cambridge City over-75s Cohort (CC75C).
Fleming J, Zhao E, O'Connor DW, Pollitt PA, Brayne C.
Int J Epidemiol. 2007 Feb;36(1):40-6.
Dementia and dementia sub-types
The prevalence of dementia as measured by the Cambridge Mental Disorders of the Elderly Examination.
O'Connor DW, Pollitt PA, Hyde JB, Fellows JL, Miller ND, Brook CPB, Reiss BB and Roth M.
Acta Psychiatrica Scandinavica, 1989; 79: 190-198.
The validity of informant histories in a community study of dementia.
O'Connor DW, Pollitt PA, Brook CP and Reiss BB.
International Journal of Geriatric Psychiatry, 1989; 4: 203-208.
Mild dementia: Perceptions and problems.
Pollitt PA, O'Connor DW and Anderson I.
Ageing and Society, 1989; 9: 261-275.
The influence of education, social class and sex on Mini-Mental State scores.
O'Connor DW, Pollitt PA, Treasure FP, Brook CP and Reiss BB.
Psychological Medicine, 1989; 19: 771-776.
Memory complaints and impairment in normal, depressed and demented elderly persons identified in a community survey.
O'Connor DW, Pollitt PA, Brook CPB and Reiss BB.
Archives General Psychiatry, 1990; 47: 224-227.
Problems reported by relatives in a community study of dementia.
O'Connor DW, Pollitt PA and Reiss BB.
British Journal of Psychiatry, 1990; 156: 835-841.
Co-existing depression and dementia in a community survey of the elderly.
O'Connor DW, Pollitt PA and Roth M.
International Psychogeriatrics, 1990; 2(1)
The contribution of CAMDEX to the Diagnosis of Mild Dementia in Community Surveys.
O'Connor DW.
Psychiatric Journal of University of Ottawa, 1990, 15(4): 216-20.
A follow-up study of dementia diagnosed in the community using the Cambridge Mental Disorders of the Elderly Examination.
O'Connor DW, Pollitt PA, Hyde JB, Fellowes JL, Miller ND and Roth M.
Acta Psychiatrica Scandinavica, 1990; 81: 78-82.
Continued clinical validation of dementia diagnosed in the community using the Cambridge Mental Disorders of the Elderly Examination.
O'Connor DW, Pollitt PA, Jones BJ, Hyde JB, Fellowes JL and Miller ND
Acta Psychiatrica Scandinavica, 1991; 83: 41-45.
The influence of education and social class on the diagnosis of dementia in a community population.
O'Connor DW, Pollitt PA and Treasure FP.
Psychological Medicine, 1991; 21: 219-224.
The Prevalence of Dementia in Europe: a collaborative study of 1980-l990 findings.
Rocca WA, Brayne C, Breteler MMB, Clarke M, Cooper B, Copeland JRM, Dartigues JF, Hofman A, Hagnell O, Heeren TJ, Engedal K, Jonker C, Lindesay J, Lobo A, Mann AH, Molsa PK, Morgan K, O'Connor DW, Sulkava R, Kay DW, Amaducci L, and Da Silva Droux A.
International Journal of Epidemiology, 1991, 20: 736-748.
Frequency and Distribution of Alzheimer's Disease in Europe: a collaborative study of l980-l990 prevalence findings.
Engedal K, Hagnell O, Heeren TJ, Jonker C, Lindesay J, Lobo A, Mann AH, Molsa PK, Morgan K, Da Silva Droux A, Sulkava R, Kay DW, Amaducci L and Dartigues JF.
Annals of Neurology, 1991; 30: 381-390.
The Prevalence of Vascular Dementia in Europe: Facts and Fragments from 1980-1990 Studies.
Hagnell O, Heeren TJ, Jonker C, Lindesay J, Lobo A, Mann AH, Molsa PK, Morgan K, O'Connor D, da Silva A, Sulkava R, Kay DWK, Amaducci L, Engedal K.
Annals of Neurology, 1991, 30: 817-824.
Incidence of dementia in a population older than 75 years in the United Kingdom.
Paykel ES, Brayne C, Huppert FA, Gill C, Barkley C, Gehlhaar E, Beardsall L, Girling DM, Pollitt P and O'Connor D.
Archives of General Psychiatry 1994; 51: 325-332.
The incidence of clinically diagnosed subtypes of dementia in an elderly population. Cambridge Project for Later Life.
Brayne C, Gill C, Huppert FA, Barkley C, Gehlhaar E, Girling D, O'Connor D and Paykel E.
British Journal of Psychiatry, 1995; 167: 255-262.
Cognitive decline in an elderly population; a two-wave study of change.
Brayne C, Gill C, Paykel ES, Huppert FA and O'Connor DW.
Psychological Medicine, 1995; 25: 673-683.
Vascular risk factors and incident dementia: results from a cohort study of the very old.
Brayne C, Gill C, Huppert FA, Barkley C, Gehlhaar E, Girling DM, O'Connor DW and Paykel ES.
Dementia, 1998; 9: 175-180.
Incidence of dementia and cognitive decline in over-75s in Cambridge: Overview of cohort study.
Paykel ES, Huppert FA and Brayne C.
Social Psychiatry and Psychiatric Epidemiology, 1998; 33: 387-392.
The EURODEM collaborative re-analysis of case-control studies of Alzheimer's disease: implications for public health.
Brayne C.
International Journal of Epidemiology, 1991; 20(Suppl 2): 568-571.
What do we mean by Alzheimer’s disease?
Marcus Richards, Carol Brayne
BMJ, 2010, 341:c4670
Neuropsychology
The influence of education, social class and sex on Mini-Mental State scores.
O'Connor DW, Pollitt PA, Treasure FP, Brook CP and Reiss BB.
Psychological Medicine, 1989; 19: 771-776.
The reliability and validity of the Mini-Mental State in a British community survey.
O'Connor DW, Pollitt PA, Hyde JB, Fellows JL, Miller ND, Brook CP and Reiss BB.
Journal of Psychiatric Research, 1989; 23(1): 87-96.
A comparison of clinical, psychometric and behavioural memory tests: findings from a community study of the early detection of dementia.
Beardsall L and Huppert FA.
International Journal of Geriatric Psychiatry 1991; 6: 295- 306.
Prospective memory impairment as an early indicator of dementia.
Huppert FA and Beardsall L.
Journal of Clinical and Experimental Neuropsychology 1993; 15(5): 805-821.
Improvement in NART word reading in demented and normal older persons using the Cambridge Contextual Reading Test.
Beardsall L and Huppert FA.
Journal of Clinical and Experimental Neuropsychology 1994; 16(2): 232-242.
CAMCOG - A concise neuropsychological test to assist dementia diagnosis: Socio-demographic determinants in an elderly population sample.
Huppert FA, Brayne C, Gill C, Paykel ES and Beardsall L.
British Journal of Clinical Psychology 1995; 34: 529-541.
Psychometric properties of the CAMCOG and its efficacy in the diagnosis of dementia.
Huppert FA, Jorm AF, Brayne C, Girling DM, Barkley C, Beardsall L and Paykel ES.
Aging, Neuropsychology and Cognition, 1996; 3(3): 201-214.
Short NART, CCRT and Spot-the-Word: Comparisons in older and demented persons.
Beardsall L and Huppert FA.
British Journal of Clinical Psychology 1997; 36(4): 619-622.
Decline across different domains of cognitive funtion in normal aging: results of a longitudinal population-based study using CAMCOG.
Cullum S, Huppert FA, McGee M, Dening T, Ahmed A, Paykel ES and Brayne C.
International Journal of Geriatric Psychiatry, 2000; 15(9): 853-62.
Cognitive functions in UK community-dwelling African Caribbean and white elders: a pilot study.
Richards M, Brayne C, Dening TR, Abas M, Carter J, Price M, Jones C and Levy R.
International Journal of Geriatric Psychiatry, 2000; 15: 621-630
Population norms for the MMSE in the very old: estimates based on longitudinal data.
Dufouil C, Clayton D, Brayne C, Chi LY, Dening TR, Paykel ES, O'Connor DW, Ahmed A, McGee MA and Huppert FA.
Neurology, 2000; 55: 1609-1613
A comparison of parametric models for the investigation of the shape of
cognitive change in the older population.
Graciela Muniz,
Fiona Matthews,
Carol Brayne
BMC Neurology 2008, 8:16
Neurobiology
Quantitative analysis of tau protein in paired helical filament preparations: implications for the role of tau protein phosphorylation in PHF assembly in Alzheimer's disease.
Wischik CM, Lai RYK, Gertz HJ, Edwards CR, Xuereb JH, Paykel ES, Brayne C, Huppert FA, Mukaetova-Ladinska EB, Roth M and Harrington CR.
Neurobiology of Aging 1995; 16(3): 409-431.
Examination of phosphorylated tau protein as a PHF-Precursor at early stage Alzheimer's disease.
Lai RYK, Gertz HJ, Wischik CM, Xuereb JH, Mukaetova-Ladinska EB, Harrington CR, Edwards PC, Mena R, Paykel ES, Brayne C, Huppert FA and Roth M.
Neurobiology of Aging 1995; 16(3): 433-445.
The relationship between clinical dementia and neuropathological staging (Braak) in a very elderly community sample.
Gertz H-J, Xuereb J, Huppert F, Brayne C, Kruger H, McGee MA, Paykel ES, Harrington C, Mukaetova- Ladinska E, O'Connor DW and Wischik CM.
European Archives of Psychiatry and Clinical Neuroscience, 1996; 246(3): 132-136.
Examination of the validity of the hierarchical model of neuropathological staging in normal ageing and Alzheimer's Disease.
Gertz H-J, Xuereb J, Huppert FA, Brayne C, McGee MA, Paykel ES, Harrington C, Mukaetova-Ladinska E, Arendt T and Wischik CM.
Acta Neuropathologica, 1998; 95: 154-158.
a-Synuclein inclusions in Alzheimer's and Lewy body diseases.
Mukaetova-Ladinska E.B, Hurt J., Jakes R., Xuereb J., Honer W.G. and Wischik C.M.
J Neuropathol Exp Neurology, 2000; 59: 408-417
Neuropathological findings in the very old: Results from the first 101 brains of a population based longitudinal study of dementing disorders.
Xuereb J, Brayne C, Dufouil C, Gertz H, Wischik C, Harrington C, Mukaetova-Ladinska E, McGee MA, O'Sullivan A, O'Connor D, Paykel ES and Huppert FA.
Ann NY Acad Sci (Suppl), 2000; 903: 490-496.
Staging of cytoskeletal and b-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's Disease.
Mukaetova-Ladinska EB, Garcia-Siera F, Hurt J, Gertz H-J, Xuereb JH, Hills R, Brayne C, Huppert FA, Paykel ES, McGee M, Jakes R, Honer W, Harrington CR and Wischik CM.
Am J Pathol, 2000; 157: 623-636.
The response of elderly community residents to request brain donation: An interim report
Lynn Beardsall 1, Claire Barkley 1, Angela O'Sullivan 2
Int J of Geriatric Psychiatry, 2004; 7(3): 199-202.
Population-based neuropathological studies of dementia: design, methods and areas of investigation – a systematic review
Zaccai J, Ince P and Brayne C
BMC Neurology 2006, 6:2
Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals
Downes EC, Robson J, Grailly E, Abdel-All Z, Xuereb J, Brayne C, Holland A, Honer WG and Mukaetova-Ladinska EB
Neuropathology and Applied Neurobiology 2008 , 34, 12–22
Alpha and gamma-Synuclein proteins are present in cerebrospinal fluid and are increased in elderly with neurodegenerative and vascular changes
Mukaetova-Ladinska EB, Milne J, Andras A, Greally E, Robson J, Abdel-All Z, Cerejeira J, Jaros E, Perry R, Brayne C, Xuereb J, Cleghorn A, Doherty J, McIntosh G, Milton I and McKeith IG
Dementia and Geriatric Cognitive Disorders 2008;26(1):32-42. Epub 2008 Jun 25
Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge City over-75s Cohort (CC75C) study
Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH, Paykel E, Mukaetova-Ladinska EB, Huppert FA, O’Sullivan A, Dening T, and the Cambridge City over-75s Cohort (CC75C) study neuropathology collaboration
Journal of Alzheimer’s Disease
Lewy Body Variant of Alzheimer's Disease: Selective Neocortical Loss of t-SNARE Proteins and Loss of MAP2 and Alpha-Synuclein in Medial Temporal Lobe
Mukaetova-Ladinska, Elizabeta B; Xuereb, John H; Garcia-Sierra, Francisco ; Hurt, Jenny ; Gertz, Herman-J ; Hills, Richard ; Brayne, Carol ; Huppert, Felicia A; Paykel, Eugene S; McGee, Magnus A; Jakes, Ross ; Honer, William G; Harrington, Charles R; Wischik, Claude M
TheScientific World JOURNAL, 2009, 9, 1463-1475
Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype
Stephen James Connelly, Elizabeta B Mukaetoval-Ladinska, Zeinab Abdel All, Joaquim Alves da Silva, Carol Brayne, William G Honer and David M A Mann
Neuropathology and Applied Neurobiology
Education, the brain and dementia: neuroprotection or compensation?
EClipSE Collaborative Members. (2010). Brain, 133; 2210–2216.
(There was much press interest, with nearly 200 articles written world wide including ABC (USA), Sydney Morning Herald (Australia), The Toronto Star (Canada), Scientific American, The Independent (UK) and BBC (UK).)
Time for a Change in the Research Paradigm for Alzheimer's Disease: The Value of a Chaotic Matrix Modeling Approach
Sally Hunter,Robert P. Friedland,Carol Brayne.
CNS Neuroscience & Therapeutics 2009 12 16 (4); 254-262.
Genetics
The tRNA Gln 4336 mitochondrial DNA variant is not a high penetrance mutation which predisposes to dementia before age 75 years.
Tysoe C, Robinson D, Brayne C, Dening T, Paykel ES, Huppert FA and Rubinsztein DC.
Journal of Medical Genetics, 1996; 33: 1002-1006.
Apolipoprotein E genotype and the prediction of cognitive decline and dementia: a prospective study of the very elderly.
Brayne C, Harrington C, Wischik C, Huppert FA, Chi LY, Xuereb J, O'Connor D and Paykel ES.
Dementia, 1996; 7: 169-174.
Analysis of the Apo E/Apo CI, angiotensin converting enzyme and methylenetetrahydrofolate reductase loci as candidates affecting human longevity.
Galinsky D, Tysoe C, Brayne C, Easton D, Huppert F, Dening T, Paykel ES and Rubinsztein DC.
Atherosclerosis, 1997; 129: 177-183.
Analysis of Alpha-1 Antichymotrypsin, Presenilin-1, Angiotensin Converting-Enzyme and Methylenetetrahydrofolate Reductase Loci as candidates for dementia.
Tysoe C, Galinsky D, Robinson D, Brayne CE, Easton DF, Huppert FA, Dening T, Paykel ES and Rubinsztein DC.
American Journal of Medical Genetics (Neuropsychiatric Genetics), 1997; 74, 207-212.
ApoE and apo CI loci are associated with dementia in younger but not in older late onset cases.
Tysoe C, Galinsky D, Robinson D, Brayne CE, Huppert FA, Dening T, Paykel ES, Easton DF and Rubinsztein DC.
Dementia and Geriatric Cognitive Disorders, 1998; 9: 191-198.
Alzheimer Disease is not associated with polymorphisms in the angiotensinogen and renin genes.
Taylor A, Ezquerra M, Bagri G, Yip A, Goumidi L, Cottel D, Easton D, Grimley Evans J, Xuereb J, Cairns NJ, Amouyel P, Chartier-Harlin M-C, Brayne C and Rubinsztein DC.
American Journal of Medical Genetics 2001; 105: 761-4.
No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease.
Cook L, Brayne CE, Easton D, Grimley Evans J, Xuereb J, Cairns NJ and Rubinsztein DC.
Annals of Neurology 2002; 52(5): 690-691.
Candidate Gene Association Studies of the a4 (CHRNA4) and ž2 (CHRNB2) Neuronal Nicotinic Acetylcholine Receptor Subunit Genes in Alzheimer's Disease.
Cook LJ, Ho Lw, Taylor AE, Brayne C, Grimley Evans J, Xuereb J, Cairns NJ, Pritchard A, Lemmon H, Mann D, St Clair D, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Owen MJ, Williams J, Lendon C and Rubinsztein DC.
Neuroscience Letters 2004; 358: 142-146.
Candidate Gene Association Studies of Genes Involved in Neuronal Cholinergic Transmission in Alzheimer's Disease suggests Choline Acetyltransferase as a candidate deserving further study.
Cook LJ, Ho LW, Wang L, Terrenoire E, Brayne C, Grimley Evans J, Xuereb J, Cairns NJ, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Williams J and Rubinsztein DC.
Am J Med Genet (Neuropsychiatric Genetics) 2005 Jan 5;132(1):5-8.
Longitudinal perspective
Cognitive Impairment in elderly people: population based estimate of the future in England, Scotland and Wales.
Melzer D, Ely M and Brayne C.
British Medical Journal, 1997; 315(23): 462.
Changes in health, disability and contact with services in a very elderly cohort: A six year follow-up study.
Dening TR, Chi L-Y, Brayne C, Huppert FA, Paykel ES and O'Connor DW.
Age and Ageing, 1998; 27: 23-33.
Estimating the true extent of cognitive decline in the old old.
Brayne C, Spiegelhalter DJ, Dufouil C, Chi L-Y, Dening TR, Paykel ES, O'Connor DW and Ahmed A, McGee MA, Huppert FA.
Journal of the American Geriatrics Society, 1999; 47(11): 1283-8.
Longitudinal studies of ageing: a key role in the evidence base for improving health and quality of life in older adults.
Huppert Felicia A., Brayne Carol, Jagger Carol and Metz David.
Age and Ageing, 2000; 29: 485-486.
Population norms for the MMSE in the very old - Estimates based on longitudinal data.
Dufouil C, Clayton D, Brayne C, Chi L-Y, Dening TR, Paykel ES, O'Connor DW, Ahmed A, McGee MA and Huppert FA.
Neurology, 2000; 55: 1609-1613.
A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.
Chatfield M, Brayne C and Matthews F
Journal of Clinical Epidemiology 2005, 58(1) 13-19
Clinical practice and services for the oldest old
Practice observed: Do general practitioners miss dementia in elderly patients?
O'Connor D, Pollitt PA, Brook CP, Reiss BB and Roth M.
British Medical Journal, 1988; 297: 1107-1110.
A community survey of mental and physical infirmity in nonagenarians.
O'Connor DW, Pollitt PA, Brook CPB and Reiss BB.
Age and Ageing, 1989; 18: 411-414.
The distribution of services to demented elderly people living in the community.
O'Connor DW, Pollitt PA, Brook CPB and Reiss BB.
International Journal of Geriatric Psychiatry, 1989; 4: 339-344.
Does early intervention reduce the number of elderly people with dementia admitted to institutions for long term care?
O'Connor DW, Pollitt PA, Brook CPB, Reiss BB and Roth M.
British Medical Journal, 1991; 302: 871-875.
Something in the heir: royal succession and the elderly.
Dening TR Brayne C Huppert FA and Rao MR.
International Journal of Geriatric Psychiatry, 1994; 9: 675.
Depressive symptoms in the very elderly - their prevalence and significance.
Girling DM, Huppert FA, Brayne C, Paykel ES, Gill C and Mathewson D.
International Journal of Geriatric Psychiatry, 1995; 10: 497-504.
The prevalence of depression in a cohort of the very elderly.
Girling DM, Barkley C, Paykel ES, Gehlhaar E, Brayne C, Gill C, Mathewson D and Huppert FA.
Journal of Affective Disorders, 1995; 34: 319-329.
Predictors of hospital contact by very elderly people:
a pilot study from a cohort of people aged 75 years and over.
Chi L-Y, Brayne C, Todd CJ, O'Connor DW, Pollitt PA.
Age and Ageing, 1995 Sep; 24(5): 382-8
Estimating the numbers and characteristics of elderly people with cognitive disability in local populations.
Ely M, Melzer D, Opit L and Brayne C.
Research Policy and Planning, 1996/1997; 14: 13-18.
Local Population Differences and the Needs of People with Cognitive Impairment.
Melzer D, Ely M and Brayne C.
International Journal
of Geriatric Psychiatry, 1997; 12:883-887.
Cognitive impairment: a challenge for community care. A comparison of the domiciliary service receipt of cognitively impaired and equally dependent physically impaired elderly women.
Ely M, Brayne C, Huppert FA, O'Connor DW and Pollitt PA.
Age and Ageing, 1997; 26: 301-308.
Suicidal thinking in community residents over eighty.
Rao R, Dening T, Brayne C and Huppert FA.
International Journal of Geriatric Psychiatry, 1997; 12: 337-343.
Attitudes towards death - a community study of octo- and nonagenerians.
Rao R, Dening T, Brayne C and Huppert F.
International Psychogeriatrics, 1997; 9(2): 213-221.
Aging and lymphocyte subpopulations: whole-blood analysis of immune markers in a large population sample of healthy elderly individuals.
Huppert FA, Solomou W, O'Connor S, Morgan K, Sussams P and Brayne C.
Exp.Gerontol, 1998; 33 (6): 593-600
Very old drivers: findings from a population cohort of people aged 84 and over.
Brayne C, Ahmed A, Dening TR, Chi L-Y, McGee M and Huppert FA.
International Journal of Epidemiology, 2000; 29: 704-707
Disability and contact with services in very elderly people.
Dening TR and Gabe R.
Reviews in Clinical Gerontology, 2000; 10: 291-309
Falls in advanced old age: recalled falls and prospective follow-up of
over-90-year-olds in the Cambridge City over-75s Cohort study.
Jane Fleming, Fiona E Matthews, Carol Brayne, Cambridge City over-75s Cohort (CC75C) study collaboration
BMC Geriatrics 2008, 8:6 doi:10.1186/1471-2318-8-6
Inability to get up after falling, subsequent time on floor, and summoning help: prospective cohort study in people over 90.
Jane Fleming, Carol Brayne, and the Cambridge City over-75s Cohort (CC75C) study collaboration.
BMJ 2008;337:a2227.
The “oldest old” in the last year of life: population-based findings from CC75C study participants aged at least 85 at death
Zhao J, Barclay S, Farquhar M, Kinmonth AL, Brayne C and Fleming J for the Cambridge City over-75s Cohort (CC75C) study collaboration
Journal of the American Geriatrics Society. 2010 Jan;58(1):1-11.
Place of death for the 'oldest old': > or =85-year-olds in the CC75C population-based cohort.
Fleming J, Zhao J, Farquhar M, Brayne C, Barclay S for the Cambridge City over-75s Cohort (CC75C) study collaboration
Br J Gen Pract. 2010 Apr;60(573):171-9.
One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors.
Terrera GM, Brayne C, Matthews F; CC75C Study Collaboration Group.
Int Psychogeriatr. 2010 Mar;22(2):291-9. Epub 2009 Nov 12.
Epidemiology of back pain in older adults: prevalence and risk factors for back pain onset
Rachael E. Docking, Jane Fleming,Carol Brayne,Jun Zhao,Gary J. Macfarlane and Gareth T. Jones on behalf of the Cambridge City over-75s Cohort Study collaboration
Rheumatology (2011) doi: 10.1093/rheumatology/ker175 First published online: May 23, 2011
Are terminal decline and its potential indicators detectable in population studies of the oldest old?
Muniz-Terrera G, Matthews FE, Stephan B, Brayne C; CC75C Collaboration Group.
Int J Geriatr Psychiatry. 2011 Jun;26(6):584-92. doi: 10.1002/gps.2566. Epub 2010 Dec 9.